Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

BACKGROUND: Oncogenic K-Ras signaling highly relies on the canonical Ras/MEK/ERK pathway to contribute to pancreatic cancer progression. However, numerous efforts of MEK inhibitors have failed to provide an optimal antitumor effect for pancreatic cancer in practice. The aim of the present work was t...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Chao, Min-Wu, Chang, Li-Hsun, Tu, Huang-Ju, Chang, Chao-Di, Lai, Mei-Jung, Chen, Yi-Ying, Liou, Jing-Ping, Teng, Che-Ming, Pan, Shiow-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540419/
https://ncbi.nlm.nih.gov/pubmed/31142371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0681-6
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