Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous work, we established that PLK4 is overexpressed in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Suri, Amreena, Bailey, Anders W., Tavares, Maurício T., Gunosewoyo, Hendra, Dyer, Connor P., Grupenmacher, Alex T., Piper, David R., Horton, Robert A., Tomita, Tadanori, Kozikowski, Alan P., Roy, Saktimayee M., Sredni, Simone T.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540285/
https://ncbi.nlm.nih.gov/pubmed/31035676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20092112
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados