THER-09. EVALUATION OF PROTEIN KINASE INHIBITORS WITH PLK4 CROSS-OVER POTENTIAL IN PEDIATRIC EMBRYONAL BRAIN TUMORS

BACKGROUND: In previous work we established that PLK4 is overexpressed and essential for proliferation and survival of pediatric embryonal brain tumors. PLK4 is a cell cycle-regulated protein recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which i...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Bailey, Anders, Suri, Amreena, Tavares, Maurício, Roy, Saktimayee, Tomita, Tadanori, Kosikowski, Alan, Watterson, Daniel, Sredni, Simone
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477257/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.216
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