Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous work, we established that PLK4 is overexpressed in...

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Udgivet i:Int J Mol Sci
Main Authors: Suri, Amreena, Bailey, Anders W., Tavares, Maurício T., Gunosewoyo, Hendra, Dyer, Connor P., Grupenmacher, Alex T., Piper, David R., Horton, Robert A., Tomita, Tadanori, Kozikowski, Alan P., Roy, Saktimayee M., Sredni, Simone T.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540285/
https://ncbi.nlm.nih.gov/pubmed/31035676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20092112
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