Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous work, we established that PLK4 is overexpressed in...

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Bibliografiset tiedot
Julkaisussa:Int J Mol Sci
Päätekijät: Suri, Amreena, Bailey, Anders W., Tavares, Maurício T., Gunosewoyo, Hendra, Dyer, Connor P., Grupenmacher, Alex T., Piper, David R., Horton, Robert A., Tomita, Tadanori, Kozikowski, Alan P., Roy, Saktimayee M., Sredni, Simone T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540285/
https://ncbi.nlm.nih.gov/pubmed/31035676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20092112
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