Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19(+) B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two...

詳細記述

保存先:
書誌詳細
出版年:CPT Pharmacometrics Syst Pharmacol
主要な著者: Stein, Andrew M., Grupp, Stephan A., Levine, John E., Laetsch, Theodore W., Pulsipher, Michael A., Boyer, Michael W., August, Keith J., Levine, Bruce L., Tomassian, Lori, Shah, Sweta, Leung, Mimi, Huang, Pai‐Hsi, Awasthi, Rakesh, Mueller, Karen Thudium, Wood, Patricia A., June, Carl H.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539725/
https://ncbi.nlm.nih.gov/pubmed/30848084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12388
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