Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19(+) B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Stein, Andrew M., Grupp, Stephan A., Levine, John E., Laetsch, Theodore W., Pulsipher, Michael A., Boyer, Michael W., August, Keith J., Levine, Bruce L., Tomassian, Lori, Shah, Sweta, Leung, Mimi, Huang, Pai‐Hsi, Awasthi, Rakesh, Mueller, Karen Thudium, Wood, Patricia A., June, Carl H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539725/
https://ncbi.nlm.nih.gov/pubmed/30848084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12388
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