Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19(+) B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two...

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Dades bibliogràfiques
Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Stein, Andrew M., Grupp, Stephan A., Levine, John E., Laetsch, Theodore W., Pulsipher, Michael A., Boyer, Michael W., August, Keith J., Levine, Bruce L., Tomassian, Lori, Shah, Sweta, Leung, Mimi, Huang, Pai‐Hsi, Awasthi, Rakesh, Mueller, Karen Thudium, Wood, Patricia A., June, Carl H.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539725/
https://ncbi.nlm.nih.gov/pubmed/30848084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12388
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