Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19(+) B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:CPT Pharmacometrics Syst Pharmacol
Egile Nagusiak: Stein, Andrew M., Grupp, Stephan A., Levine, John E., Laetsch, Theodore W., Pulsipher, Michael A., Boyer, Michael W., August, Keith J., Levine, Bruce L., Tomassian, Lori, Shah, Sweta, Leung, Mimi, Huang, Pai‐Hsi, Awasthi, Rakesh, Mueller, Karen Thudium, Wood, Patricia A., June, Carl H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539725/
https://ncbi.nlm.nih.gov/pubmed/30848084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12388
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