Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia

BACKGROUND: Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). METHODS: We evaluated the cellular kinetics of tisagenlecleucel, the effec...

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Udgivet i:Clin Cancer Res
Main Authors: Mueller, Karen Thudium, Waldron, Edward, Grupp, Stephan A., Levine, John E., Laetsch, Theodore W., Pulsipher, Michael A., Boyer, Michael W., August, Keith J., Hamilton, Jason, Awasthi, Rakesh, Stein, Andrew M., Sickert, Denise, Chakraborty, Abhijit, Levine, Bruce L., June, Carl H., Tomassian, Lori, Shah, Sweta S., Leung, Mimi, Taran, Tetiana, Wood, Patricia A., Maude, Shannon L.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433345/
https://ncbi.nlm.nih.gov/pubmed/30190371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0758
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