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Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells

AS1411 is a G-rich DNA oligonucleotide that functions as an aptamer of the protein nucleolin, found at high levels on the surface of cancer cells but not on the surface of normal cells. Herein, we have studied AS1411 as a supramolecular carrier for the delivery of an acridine-based G-quadruplex liga...

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Publicat a:Sci Rep
Autors principals: Carvalho, Josué, Paiva, Artur, Cabral Campello, Maria Paula, Paulo, António, Mergny, Jean-Louis, Salgado, Gilmar F., Queiroz, João A., Cruz, Carla
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538641/
https://ncbi.nlm.nih.gov/pubmed/31138870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44388-9
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