Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers

Conjugated bile acids (CBAs), such as tauroursodeoxycholic acid (TUDCA), are known to resolve the inflammatory and unfolded protein response (UPR) in inflammatory diseases, such as asthma. Whether CBAs exert their beneficial effects on allergic airway responses via 1 arm or several arms of the UPR,...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Nakada, Emily M., Bhakta, Nirav R., Korwin-Mihavics, Bethany R., Kumar, Amit, Chamberlain, Nicolas, Bruno, Sierra R., Chapman, David G., Hoffman, Sidra M., Daphtary, Nirav, Aliyeva, Minara, Irvin, Charles G., Dixon, Anne E., Woodruff, Prescott G., Amin, Shantu, Poynter, Matthew E., Desai, Dhimant H., Anathy, Vikas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538331/
https://ncbi.nlm.nih.gov/pubmed/31045581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98101
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