Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers

Conjugated bile acids (CBAs), such as tauroursodeoxycholic acid (TUDCA), are known to resolve the inflammatory and unfolded protein response (UPR) in inflammatory diseases, such as asthma. Whether CBAs exert their beneficial effects on allergic airway responses via 1 arm or several arms of the UPR,...

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Publicat a:JCI Insight
Autors principals: Nakada, Emily M., Bhakta, Nirav R., Korwin-Mihavics, Bethany R., Kumar, Amit, Chamberlain, Nicolas, Bruno, Sierra R., Chapman, David G., Hoffman, Sidra M., Daphtary, Nirav, Aliyeva, Minara, Irvin, Charles G., Dixon, Anne E., Woodruff, Prescott G., Amin, Shantu, Poynter, Matthew E., Desai, Dhimant H., Anathy, Vikas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538331/
https://ncbi.nlm.nih.gov/pubmed/31045581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98101
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