Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers

Conjugated bile acids (CBAs), such as tauroursodeoxycholic acid (TUDCA), are known to resolve the inflammatory and unfolded protein response (UPR) in inflammatory diseases, such as asthma. Whether CBAs exert their beneficial effects on allergic airway responses via 1 arm or several arms of the UPR,...

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Publicado no:JCI Insight
Main Authors: Nakada, Emily M., Bhakta, Nirav R., Korwin-Mihavics, Bethany R., Kumar, Amit, Chamberlain, Nicolas, Bruno, Sierra R., Chapman, David G., Hoffman, Sidra M., Daphtary, Nirav, Aliyeva, Minara, Irvin, Charles G., Dixon, Anne E., Woodruff, Prescott G., Amin, Shantu, Poynter, Matthew E., Desai, Dhimant H., Anathy, Vikas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538331/
https://ncbi.nlm.nih.gov/pubmed/31045581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98101
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