Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody

Biased agonism is a paradigm that may explain the selective activation of a signaling pathway via a GPCR that activates multiple signals. The autoantibody-induced inactivation of the calcium-sensing receptor (CaSR) causes acquired hypocalciuric hypercalcemia (AHH). Here, we describe an instructive c...

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Publicado en:JCI Insight
Autores principales: Makita, Noriko, Ando, Takao, Sato, Junichiro, Manaka, Katsunori, Mitani, Koji, Kikuchi, Yasuko, Niwa, Takayoshi, Ootaki, Masanori, Takeba, Yuko, Matsumoto, Naoki, Kawakami, Atsushi, Ogawa, Toshihisa, Nangaku, Masaomi, Iiri, Taroh
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538321/
https://ncbi.nlm.nih.gov/pubmed/30996138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126449
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