An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations

The seven-spanning calcium-sensing receptor (CaSR) activates multiple G proteins including Gq and Gi, and thereby activates a variety of second messengers and inhibits parathyroid hormone (PTH) secretion. However, the exact signaling mechanisms underlying the functional activity of CaSR are not yet...

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Autores principales: Makita, Noriko, Sato, Junichiro, Manaka, Katsunori, Shoji, Yuki, Oishi, Atsuro, Hashimoto, Makiko, Fujita, Toshiro, Iiri, Taroh
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838439/
https://ncbi.nlm.nih.gov/pubmed/17372216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701290104
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