Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist

Disease-causing mutations in G protein-coupled receptor (GPCR) genes, including the V2 vasopressin receptor (V2R) gene, often cause misfolded receptors, leading to a defect in plasma membrane trafficking. A novel V2R mutation, T273M, identified in a boy with partial nephrogenic diabetes insipidus (N...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Makita, Noriko, Sato, Tomohiko, Yajima-Shoji, Yuki, Sato, Junichiro, Manaka, Katsunori, Eda-Hashimoto, Makiko, Ootaki, Masanori, Matsumoto, Naoki, Nangaku, Masaomi, Iiri, Taroh
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077185/
https://ncbi.nlm.nih.gov/pubmed/27601473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.733220
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