V2 Vasopressin Receptor (V2R) Mutations in Partial Nephrogenic Diabetes Insipidus Highlight Protean Agonism of V2R Antagonists

Inactivating mutations of the V2 vasopressin receptor (V2R) cause cross-linked congenital nephrogenic diabetes insipidus (NDI), resulting in renal resistance to the antidiuretic hormone AVP. In two families showing partial NDI, characterized by an apparently normal response to diagnostic tests and a...

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Detalhes bibliográficos
Main Authors: Takahashi, Kazuhiro, Makita, Noriko, Manaka, Katsunori, Hisano, Masataka, Akioka, Yuko, Miura, Kenichiro, Takubo, Noriyuki, Iida, Atsuko, Ueda, Norishi, Hashimoto, Makiko, Fujita, Toshiro, Igarashi, Takashi, Sekine, Takashi, Iiri, Taroh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265889/
https://ncbi.nlm.nih.gov/pubmed/22144672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268797
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