V2 Vasopressin Receptor (V2R) Mutations in Partial Nephrogenic Diabetes Insipidus Highlight Protean Agonism of V2R Antagonists

Inactivating mutations of the V2 vasopressin receptor (V2R) cause cross-linked congenital nephrogenic diabetes insipidus (NDI), resulting in renal resistance to the antidiuretic hormone AVP. In two families showing partial NDI, characterized by an apparently normal response to diagnostic tests and a...

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Autori principali: Takahashi, Kazuhiro, Makita, Noriko, Manaka, Katsunori, Hisano, Masataka, Akioka, Yuko, Miura, Kenichiro, Takubo, Noriyuki, Iida, Atsuko, Ueda, Norishi, Hashimoto, Makiko, Fujita, Toshiro, Igarashi, Takashi, Sekine, Takashi, Iiri, Taroh
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265889/
https://ncbi.nlm.nih.gov/pubmed/22144672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268797
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