Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

Advanced age and the APOE ε4 allele are the two biggest risk factors for Alzheimer’s disease (AD) and declining cognitive function. We describe a universal gauge to measure molecular brain age using transcriptome analysis of four human postmortem cohorts (n = 673, ages 25–97) free of neurological di...

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Publicat a:Life Sci Alliance
Autors principals: Glorioso, Christin A, Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard P
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537750/
https://ncbi.nlm.nih.gov/pubmed/31133613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900303
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