Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

Advanced age and the APOE ε4 allele are the two biggest risk factors for Alzheimer’s disease (AD) and declining cognitive function. We describe a universal gauge to measure molecular brain age using transcriptome analysis of four human postmortem cohorts (n = 673, ages 25–97) free of neurological di...

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Bibliografiske detaljer
Udgivet i:Life Sci Alliance
Main Authors: Glorioso, Christin A, Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard P
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537750/
https://ncbi.nlm.nih.gov/pubmed/31133613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900303
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