Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

Advanced age and the APOE ε4 allele are the two biggest risk factors for Alzheimer’s disease (AD) and declining cognitive function. We describe a universal gauge to measure molecular brain age using transcriptome analysis of four human postmortem cohorts (n = 673, ages 25–97) free of neurological di...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Life Sci Alliance
Egile Nagusiak: Glorioso, Christin A, Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard P
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Life Science Alliance LLC 2019
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537750/
https://ncbi.nlm.nih.gov/pubmed/31133613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900303
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