THE APOE-ε4 ALLELE AND AGE SYNERGISTICALLY DRIVE DISEASE PROGRESSION IN ALZHEIMER’S DISEASE

The Apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD) and other neurodegenerative dementias. Cross-sectional case-control studies suggest that the effect of APOE-ε4 decreases in old age. However, since APOE- ε4 is associated with mortality, these stu...

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Detalhes bibliográficos
Publicado no:Innov Aging
Main Authors: Kleineidam, Luca, Zammit, Andrea R, DeVito, Alyssa, Lipton, Richard B, Peters, Oliver, Ramirez, Alfredo, Wagner, Michael, Terrera, Graciela Muniz
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Session Lb3620 (Late Breaking Poster)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846511/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igz038.3427
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