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Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Diprovocim is a recently discovered exceptionally potent, synthetic small molecule agonist of TLR2/TLR1 and has shown significant adjuvant activity in anticancer vaccination against murine melanoma. Since Diprovocim bears no structural similarity to the canonical lipopeptide ligands of TLR2/TLR1, we...

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書目詳細資料
發表在:J Med Chem
Main Authors: Su, Lijing, Wang, Ying, Wang, Junmei, Mifune, Yuto, Morin, Matthew D., Jones, Brian T., Moresco, Eva Marie Y., Boger, Dale L., Beutler, Bruce, Zhang, Hong
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537610/
https://ncbi.nlm.nih.gov/pubmed/30829478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01583
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