Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis

BACKGROUND: Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer. ERK1/2 inhibitor can suppress growth of KRAS-mutant pancreatic tumors by targeting cancer cell. However, no studies have...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Yan, Zilong, Ohuchida, Kenoki, Fei, Shuang, Zheng, Biao, Guan, Weiyu, Feng, Haimin, Kibe, Shin, Ando, Yohei, Koikawa, Kazuhiro, Abe, Toshiya, Iwamoto, Chika, Shindo, Koji, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Ohtsuka, Takao, Mizumoto, Kazuhiro, Hashizume, Makoto, Nakamura, Masafumi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537367/
https://ncbi.nlm.nih.gov/pubmed/31133044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1226-8
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