N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions

BACKGROUND: Pancreatic stellate cells (PSCs) occupy the majority of the pancreatic cancer microenvironment, contributing to aggressive behavior of pancreatic cancer cells (PCCs). Recently, anti-fibrotic agents have proven to be an effective strategy against cancer, but clinical trials have shown lit...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Feng, Haimin, Moriyama, Taiki, Ohuchida, Kenoki, Sheng, Nan, Iwamoto, Chika, Shindo, Koji, Shirahane, Kengo, Ikenaga, Naoki, Nagai, Shuntaro, Nakata, Kohei, Mizumoto, Kazuhiro, Nakamura, Masafumi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050903/
https://ncbi.nlm.nih.gov/pubmed/33858491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01939-1
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