Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells

Pancreatic cancer progression involves components of the tumor microenvironment, including stellate cells, immune cells, endothelial cells, and the extracellular matrix. Although peripancreatic fat is the main stromal component involved in extra-pancreatic invasion, its roles in local invasion and m...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Okumura, Takashi, Ohuchida, Kenoki, Sada, Masafumi, Abe, Toshiya, Endo, Sho, Koikawa, Kazuhiro, Iwamoto, Chika, Miura, Daisuke, Mizuuchi, Yusuke, Moriyama, Taiki, Nakata, Kohei, Miyasaka, Yoshihiro, Manabe, Tatsuya, Ohtsuka, Takao, Nagai, Eishi, Mizumoto, Kazuhiro, Oda, Yoshinao, Hashizume, Makoto, Nakamura, Masafumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392327/
https://ncbi.nlm.nih.gov/pubmed/28407685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15430
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