SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis

Cholangiocarcinoma (CCA) is an extremely invasive malignancy with late diagnosis and unfavorable prognosis. Surgery and chemotherapy are still not effective in improving outcomes in CCA patients. It is crucial to explore a novel therapeutic target for treating CCA. An NAD‐dependent deacetylase also...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Xu, Lei, Li, Yang, Zhou, Lixing, Dorfman, Robert Gregory, Liu, Li, Cai, Rui, Jiang, Chenfei, Tang, Dehua, Wang, Yuming, Zou, Xiaoping, Wang, Lei, Zhang, Mingming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536927/
https://ncbi.nlm.nih.gov/pubmed/30993888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2089
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