PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

PGC1α acts as a central regulator of mitochondrial metabolism, whose role in cancer progression has been highlighted but remains largely undefined. Especially, it is completely unknown about the effect of PGC1α on cholangiocarcinoma (CCA). Here we showed that PGC1α overexpression had no impact on CC...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Dan Li, Wang, Chaoqun, Ma, Panfei, Yu, Qingan, Gu, Mingqi, Dong, Liqian, Jiang, Wenjing, Pan, Shangha, Xie, Changming, Han, Jihua, Lan, Yaliang, Sun, Jing, Sheng, Ping, Liu, Kunpeng, Wu, Yaohua, Liu, Lianxin, Ma, Yong, Jiang, Hongchi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919932/
https://ncbi.nlm.nih.gov/pubmed/29700317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0494-0
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