Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis

BACKGROUND: Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has often been described as an oncoprotein that preferentially contributes to the Warbu...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Zhang, Mingming, Pan, Yida, Tang, Dehua, Dorfman, Robert Gregory, Xu, Lei, Zhou, Qian, Zhou, Lixing, Wang, Yuming, Li, Yang, Yin, Yuyao, Kong, Bo, Friess, Helmut, Zhao, Shimin, Wu, Jian-lin, Wang, Lei, Zou, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417221/
https://ncbi.nlm.nih.gov/pubmed/30866966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0332-8
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