Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis

BACKGROUND: Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has often been described as an oncoprotein that preferentially contributes to the Warbu...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Zhang, Mingming, Pan, Yida, Tang, Dehua, Dorfman, Robert Gregory, Xu, Lei, Zhou, Qian, Zhou, Lixing, Wang, Yuming, Li, Yang, Yin, Yuyao, Kong, Bo, Friess, Helmut, Zhao, Shimin, Wu, Jian-lin, Wang, Lei, Zou, Xiaoping
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417221/
https://ncbi.nlm.nih.gov/pubmed/30866966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0332-8
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