Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis

BACKGROUND: Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has often been described as an oncoprotein that preferentially contributes to the Warbu...

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Foilsithe in:Cell Commun Signal
Main Authors: Zhang, Mingming, Pan, Yida, Tang, Dehua, Dorfman, Robert Gregory, Xu, Lei, Zhou, Qian, Zhou, Lixing, Wang, Yuming, Li, Yang, Yin, Yuyao, Kong, Bo, Friess, Helmut, Zhao, Shimin, Wu, Jian-lin, Wang, Lei, Zou, Xiaoping
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2019
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417221/
https://ncbi.nlm.nih.gov/pubmed/30866966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0332-8
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