Down-regulation of HDAC3 inhibits growth of cholangiocarcinoma by inducing apoptosis

Class I histone deacetylases (HDACs) inhibit expression of tumor suppressor genes by removing acetyl groups from histone lysine residues, thereby increasing cancer cell survival and proliferation. We evaluated the expression of class I HDACs in cholangiocarcinoma (CCA). HDAC3 expression was specific...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Zhang, Mingming, Yin, Yuyao, Dorfman, Robert G., Zou, Tianhui, Pan, Yida, Li, Yang, Wang, Yuming, Zhou, Qian, Zhou, Lixing, Kong, Bo, Friess, Helmut, Zhang, Jun, Zhao, Shimin, Wang, Lei, Zou, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725102/
https://ncbi.nlm.nih.gov/pubmed/29245911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19660
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