Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis

BACKGROUND: Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has often been described as an oncoprotein that preferentially contributes to the Warbu...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Commun Signal
Hauptverfasser: Zhang, Mingming, Pan, Yida, Tang, Dehua, Dorfman, Robert Gregory, Xu, Lei, Zhou, Qian, Zhou, Lixing, Wang, Yuming, Li, Yang, Yin, Yuyao, Kong, Bo, Friess, Helmut, Zhao, Shimin, Wu, Jian-lin, Wang, Lei, Zou, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417221/
https://ncbi.nlm.nih.gov/pubmed/30866966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0332-8
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