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Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal

Metabolic dysfunction of endothelial cells in hyperglycemia contributes to the development of vascular complications of diabetes where increased reactive glycating agent, methylglyoxal (MG), is involved. We assessed if increased MG glycation induced proteotoxic stress, identifying related metabolic...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Irshad, Zehra, Xue, Mingzhan, Ashour, Amal, Larkin, James R., Thornalley, Paul J., Rabbani, Naila
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536510/
https://ncbi.nlm.nih.gov/pubmed/31133647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44358-1
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