PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway

OBJECTIVES: Although targeted therapy has revolutionized the treatment of gastrointestinal stromal tumours (GIST), it is almost never curative in GIST, and resistance commonly develops. One potential strategy is to combine targeted therapy with immunotherapy. MATERIALS AND METHODS: We first studied...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Zhao, Rui, Song, Yinghan, Wang, Yong, Huang, Yuqian, Li, Zhigui, Cui, Yaping, Yi, Mengshi, Xia, Lin, Zhuang, Wen, Wu, Xiaoting, Zhou, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536456/
https://ncbi.nlm.nih.gov/pubmed/30714229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12571
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