PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway

OBJECTIVES: Although targeted therapy has revolutionized the treatment of gastrointestinal stromal tumours (GIST), it is almost never curative in GIST, and resistance commonly develops. One potential strategy is to combine targeted therapy with immunotherapy. MATERIALS AND METHODS: We first studied...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Prolif
Egile Nagusiak: Zhao, Rui, Song, Yinghan, Wang, Yong, Huang, Yuqian, Li, Zhigui, Cui, Yaping, Yi, Mengshi, Xia, Lin, Zhuang, Wen, Wu, Xiaoting, Zhou, Yong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536456/
https://ncbi.nlm.nih.gov/pubmed/30714229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12571
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