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New analogs of SYA013 as sigma-2 ligands with anticancer activity
Our previous study has revealed 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one-2HCI (SYA013) 1 as a sigma ligand with moderate selectivity for the sigma-2 receptor. Given the overexpression of sigma receptors in solid tumors and reports of sigma ligands with anticancer activi...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6536312/ https://ncbi.nlm.nih.gov/pubmed/30987780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.04.012 |
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