New analogs of SYA013 as sigma-2 ligands with anticancer activity

Our previous study has revealed 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one-2HCI (SYA013) 1 as a sigma ligand with moderate selectivity for the sigma-2 receptor. Given the overexpression of sigma receptors in solid tumors and reports of sigma ligands with anticancer activi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Asong, Gladys, Zhu, Xue Y, Bricker, Barbara, Andey, Terrick, Amissah, Felix, Lamango, Nazarius, Ablordeppey, Seth Y
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536312/
https://ncbi.nlm.nih.gov/pubmed/30987780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.04.012
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