Further Evaluation of the Tropane Analogs of Haloperidol

Previous work from our labs has indicated that a tropane analog of haloperidol with potent D(2) binding but designed to avoid the formation of MPP+-like metabolites, such as 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)pyridin-1-ium (BCPP+) still produced catalepsy, suggesting a strong role f...

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Autores principales: Sampson, Dinithia, Bricker, Barbara, Zhu, Xue Y., Peprah, Kwakye, Lamango, Nazarius S., Setola, Vincent, Roth, Bryan L., Ablordeppey, Seth Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146722/
https://ncbi.nlm.nih.gov/pubmed/25070422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.018
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