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Hydrogen-deuterium exchange supports independent membrane-interfacial fusion peptide and transmembrane domains in subunit 2 of influenza virus hemagglutinin protein, a structured and aqueous-protected connection between the fusion peptide and soluble ectodomain, and the importance of membrane apposition by the trimer-of-hairpins structure

The influenza virus hemagglutinin (HA) protein has HA1 and HA2 subunits, which form an initial complex. HA1’s bind host cell sialic acids which triggers endocytosis, HA1/HA2 separation, and HA2-mediated fusion between virus and endosome membranes. We report hydrogen-deuterium exchange-mass spectrome...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Ranaweera, Ahinsa, Ratnayake, Punsisi U., Ekanayaka, E. A. Prabodha, DeClercq, Robin, Weliky, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536117/
https://ncbi.nlm.nih.gov/pubmed/31008587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01272
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