Small Molecule Inhibitors of the BfrB–Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity

[Image: see text] The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the st...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Punchi Hewage, Achala N. D., Yao, Huili, Nammalwar, Baskar, Gnanasekaran, Krishna Kumar, Lovell, Scott, Bunce, Richard A., Eshelman, Kate, Phaniraj, Sahishna M., Lee, Molly M., Peterson, Blake R., Battaile, Kevin P., Reitz, Allen B., Rivera, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535718/
https://ncbi.nlm.nih.gov/pubmed/31038945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b00394
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