Small Molecule Inhibitors of the Bacterioferritin (BfrB)–Ferredoxin (Bfd) Complex Kill Biofilm-Embedded Pseudomonas aeruginosa Cells

[Image: see text] Bacteria depend on a well-regulated iron homeostasis to survive adverse environments. A key component of the iron homeostasis machinery is the compartmentalization of Fe(3+) in bacterioferritin and its subsequent mobilization as Fe(2+) to satisfy metabolic requirements. In Pseudomo...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Soldano, Anabel, Yao, Huili, Punchi Hewage, Achala N. D., Meraz, Kevin, Annor-Gyamfi, Joel K., Bunce, Richard A., Battaile, Kevin P., Lovell, Scott, Rivera, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802073/
https://ncbi.nlm.nih.gov/pubmed/33269912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00669
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