Small Molecule Inhibitors of the BfrB–Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity

[Image: see text] The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the st...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Punchi Hewage, Achala N. D., Yao, Huili, Nammalwar, Baskar, Gnanasekaran, Krishna Kumar, Lovell, Scott, Bunce, Richard A., Eshelman, Kate, Phaniraj, Sahishna M., Lee, Molly M., Peterson, Blake R., Battaile, Kevin P., Reitz, Allen B., Rivera, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535718/
https://ncbi.nlm.nih.gov/pubmed/31038945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b00394
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