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In Vitro and In Vivo Exposure-Effect Relationship of Liposomal Amphotericin B against Aspergillus fumigatus
In vitro pharmacokinetic/pharmacodynamic data of liposomal amphotericin B (L-AMB) were compared with animal data from neutropenic and nonneutropenic models of azole-susceptible and azole-resistant invasive aspergillosis. L-AMB was equally effective. The in vitro fC(max) (maximum concentration of fre...
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| Published in: | Antimicrob Agents Chemother |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6535574/ https://ncbi.nlm.nih.gov/pubmed/30962332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02673-18 |
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