A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers

Staphylococcus aureus causes serious bacterial infections with high morbidity and mortality, necessitating the discovery of new antibiotics. DSTA4637S is a novel antibody-antibiotic conjugate designed to target intracellular S. aureus that is not adequately eliminated by current standard-of-care ant...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Peck, Melicent, Rothenberg, Michael E., Deng, Rong, Lewin-Koh, Nicholas, She, Gaohong, Kamath, Amrita V., Carrasco-Triguero, Montserrat, Saad, Ola, Castro, Aide, Teufel, Lisa, Dickerson, Daniel S., Leonardelli, Marisa, Tavel, Jorge A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Clinical Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535527/
https://ncbi.nlm.nih.gov/pubmed/30910894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02588-18
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