Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate

The aim of this study was to investigate the pharmacokinetics of oseltamivir phosphate, a prodrug, and its active moiety in plasma and lung after its nebulization and intravenous administration in rats. Only 2% of prodrug was converted into active moiety presystematically, attesting to a low advanta...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Carrez, Romain, Brillault, Julien, Grégoire, Nicolas, Lamarche, Isabelle, Laroche, Julian, Couet, William, Marchand, Sandrine
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535510/
https://ncbi.nlm.nih.gov/pubmed/30962337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00074-19
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