An oncolytic herpes virus expressing E-cadherin resists NK cell clearance and improves viral spread and glioblastoma virotherapy

An engineered oncolytic herpes virus shows enhanced intratumoral spread, resistance to NK cell clearance and improved efficacy against brain cancer in mice.

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Bibliographic Details
Published in:Nat Biotechnol
Main Authors: Xu, Bo, Ma, Rui, Russell, Luke, Yoo, Ji Young, Han, Jianfeng, Cui, Hanwei, Yi, Ping, Zhang, Jianying, Nakashima, Hiroshi, Dai, Hongsheng, Chiocca, E. Antonio, Kaur, Balveen, Caligiuri, Michael A, Yu, Jianhua
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535376/
https://ncbi.nlm.nih.gov/pubmed/30475349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4302
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