An oncolytic herpes virus expressing E-cadherin resists NK cell clearance and improves viral spread and glioblastoma virotherapy

An engineered oncolytic herpes virus shows enhanced intratumoral spread, resistance to NK cell clearance and improved efficacy against brain cancer in mice.

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Xu, Bo, Ma, Rui, Russell, Luke, Yoo, Ji Young, Han, Jianfeng, Cui, Hanwei, Yi, Ping, Zhang, Jianying, Nakashima, Hiroshi, Dai, Hongsheng, Chiocca, E. Antonio, Kaur, Balveen, Caligiuri, Michael A, Yu, Jianhua
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535376/
https://ncbi.nlm.nih.gov/pubmed/30475349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4302
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