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HIV-1 Protein gp120 Induces Mouse Lung Fibroblast-to-Myofibroblast Transdifferentiation via CXCR4 Activation
BACKGROUND: Individuals with HIV have ~ 2-fold increased risk of developing pulmonary fibrosis. The mechanism(s) by which this occurs has yet to be determined. HIV-1 protein gp120 activates CXCR4 in the lymphocyte, promoting a variety of intracellular signaling pathways including those common to TGF...
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| Опубликовано в: : | Am J Med Sci |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6535111/ https://ncbi.nlm.nih.gov/pubmed/31000424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjms.2019.03.006 |
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