Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR)

Targeted drug delivery platforms can increase the concentration of drugs in specific cell populations, reduce adverse effects, and hence improve the therapeutic effect of drugs. Herein, we designed two conjugates by installing the targeting ligand GalNAc (N-acetylgalactosamine) onto atorvastatin (AT...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Zhang, Youxi, Zhang, Xinfu, Zeng, Chunxi, Li, Bin, Zhang, Chengxiang, Li, Wenqing, Hou, Xucheng, Dong, Yizhou
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535107/
https://ncbi.nlm.nih.gov/pubmed/31005367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.04.019
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