Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR)

Targeted drug delivery platforms can increase the concentration of drugs in specific cell populations, reduce adverse effects, and hence improve the therapeutic effect of drugs. Herein, we designed two conjugates by installing the targeting ligand GalNAc (N-acetylgalactosamine) onto atorvastatin (AT...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Zhang, Youxi, Zhang, Xinfu, Zeng, Chunxi, Li, Bin, Zhang, Chengxiang, Li, Wenqing, Hou, Xucheng, Dong, Yizhou
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535107/
https://ncbi.nlm.nih.gov/pubmed/31005367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.04.019
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