Concomitant KRAS and BRAF mutations in colorectal cancer

BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We pres...

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Publicado en:J Gastrointest Oncol
Autores principales: Midthun, Lauren, Shaheen, Shagufta, Deisch, Jeremy, Senthil, Maheswari, Tsai, James, Hsueh, Chung-Tsen
Formato: Artigo
Lenguaje:Inglês
Publicado: AME Publishing Company 2019
Materias:
Case Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534722/
https://ncbi.nlm.nih.gov/pubmed/31183211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo.2019.01.10
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