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Concomitant KRAS and BRAF mutations in colorectal cancer

BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. While previously considered mutually exclusive, concomitant mutations in both KRAS and BRAF genes have been identified in colorectal cancer (CRC). The clinical outcome of these patients remains undetermined. We pres...

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Détails bibliographiques
Publié dans:J Gastrointest Oncol
Auteurs principaux: Midthun, Lauren, Shaheen, Shagufta, Deisch, Jeremy, Senthil, Maheswari, Tsai, James, Hsueh, Chung-Tsen
Format: Artigo
Langue:Inglês
Publié: AME Publishing Company 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534722/
https://ncbi.nlm.nih.gov/pubmed/31183211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo.2019.01.10
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