The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

In mice, the initial stage of nephrotoxic serum-induced nephritis (NTN) mimics antibody-mediated human glomerulonephritis. Local immune deposits generate tumor necrosis factor (TNF), which activates pro-inflammatory pathways in glomerular endothelial cells (GEC) and podocytes. Because TNF receptors...

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Udgivet i:Kidney Int
Main Authors: Madaio, Michael P., Czikora, Istvan, Kvirkvelia, Nino, McMenamin, Malgorzata, Yue, Qiang, Liu, Ting, Flores-Toque, Haroldo, Sridhar, Supriya, Covington, Katherine, Alaisami, Rabei, O’Connor, Paul, Caldwell, Robert W., Chen, Jian-Kang, Clauss, Matthias, Brands, Michael W., Eaton, Douglas C., Romero, Maritza J., Lucas, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534471/
https://ncbi.nlm.nih.gov/pubmed/30905471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.12.022
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