Human anti-α3(IV)NC1 antibody drug conjugates target glomeruli to resolve nephritis

Current therapies to limit kidney disease progression lack specificity and often have systemic toxicity. To approach this problem, we postulated that a human monoclonal antibody (F1.1), directed against the noncollagenous-1 domain (NC1) of α3(IV) collagen that localizes in glomeruli, could serve as...

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Bibliographic Details
Published in:Am J Physiol Renal Physiol
Main Authors: Kvirkvelia, Nino, McMenamin, Malgorzata, Gutierrez, Vanessa Iris, Lasareishvili, Besarion, Madaio, Michael P.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Rapid Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609920/
https://ncbi.nlm.nih.gov/pubmed/26290372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00289.2015
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