Kidney targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction

To investigate the role of protein kinase C-α (PKC-α) in glomerulonephritis, the capacity of PKC-α inhibition to reverse the course of established nephrotoxic nephritis (NTN) was evaluated. Nephritis was induced by a single injection of nephrotoxic serum and after its onset, a PKC-α inhibitor was ad...

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Vydáno v:Kidney Int
Hlavní autoři: Kvirkvelia, Nino, McMenamin, Malgorzata, Warren, Marie, Jadeja, Ravirajsinh, Kodeboyina, Sai Karthik, Sharma, Ashok, Zhi, Wenbo, O’Conor, Paul M., Raju, Raghavan, Lucas, Rudolf, Madaio, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084791/
https://ncbi.nlm.nih.gov/pubmed/29731111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.01.032
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