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Double Nitroxide Labeling by Copper-Catalyzed Azide–Alkyne Cycloadditions with Noncanonical Amino Acids for Electron Paramagnetic Resonance Spectroscopy

[Image: see text] Electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling (SDSL) is an important tool to obtain long-range distance restraints for protein structural research. We here study a variety of azide- and alkyne-bearing noncanonical amino acids (ncAA) in...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Widder, Pia, Berner, Frederic, Summerer, Daniel, Drescher, Malte
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534342/
https://ncbi.nlm.nih.gov/pubmed/30998314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b01111
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